Triple Negs ..

[yowyow]

If I had an insy tiny bit of microscopically invasive from DCIS to IDC I would do chemo
because hormone negs respond so well to chemo (see previously posted article in this thread)
THATS only my opinion though

[yowyow]

Hey sparky - Think of it this way - In a way we are very lucky - we can only do chemo or radiotherapy
none of that yuk hormone therapy for 5 years

Its only when we get mets that the treatment options are limited - chemo only really at this stage
but there are so many more that are available now - they even have preventative stuff in trials

I had DCIS - 5cm - I did not get a hormone receptor report on that - (only on 14mm invasive tumor)
Only that the DCIS was high grade with all sorts of nasties - cribriform - associated comedo necrosis and microcalcifications BLAH BLAH BLAH. I just hang onto the fact that my invasive tumor was 1.4cm - buggar the 5cm DCIS
because THATS not invasive

DCIS cannot be invasive - it cannot invade your body - It can turn into IDC
and if that is triple neg - no matter if nodes + or not you would be
offered chemo.


chicky - your a champ

[Doxiamonev]

Hey Sparkles,
I'm triple neg too. There is a lot of info on triple neg on this forum for you to read or simply ask away, we are always here to answer your questions

[karene8]

Welcome Sherri,

We are special and I always new you were anyhow !

Love ya Karen X

[Gail]

Sparkles, you are obviously upset but you make me laugh, you have a very dry sense of humor that appeals to me.

[sparkles3001]

Hi Girls,
Just found out yesterday that I am triple neg too. Does this make me special now? Am I now in another twisted unique club now?
I don't really know what it means for me. Have to make another appointment with my specialist again to find out if this changes things for me...
Sparkles

[cas145]

Wow this would be wonderful thanks Nav Cas

[karene8]

Hey girls,

Yep another triple-neg here, lucky me

Karen XXX

[yowyow]

Thanks for the link Lisa.

Great it should (if trials do what they think) help most "types" of BC

Especially good though that they are doing the trials on trip negs

[Lisa8]

I just looked on the breastcancer.org triple negative discussion board and got a link to Dr Joseph Barr talking about his vaccine trial.

http://abcnews.go.com/video/playerIndex?id=6040929

[Debs]

Great news wonder how long it will take before we know this will work. Wow if its possible it would be an amazing wonderful thing. Thanks Nav for posting and keeping us informed.

[Lisa8]

Thanks Nav, I really hope this is possible.

[Doxiamonev]

WOW I do hope so

[yowyow]

Ok OK oK...... am I getting too excited ? (posted this in research section too)

YENCKINS......... could we be on the way to finding further treatment for triple negs ????

a potential for having a targeted therapy for triple negatives:

ScienceDaily (Dec. 12, 2008) — Research out of the Ireland Cancer Center of University Hospitals Case Medical Center has found that the vast majority of triple negative breast cancers express the MUC-1 target. This first-of-its-kind finding, presented today at the San Antonio Breast Cancer Symposium, has paved the way for an upcoming vaccine trial for patients with early stage triple negative breast cancer that could potentially prevent recurrence of this aggressive type of breast cancer.

Joseph Baar, MD, PhD, Director of Breast Cancer Research at the Ireland Cancer Center, and colleagues analyzed 53 tumors and determined that 92 percent of them expressed MUC-1. These findings support their theory that this MUC-1 protein on breast cancer cells could be a target for a novel vaccine using the patient's immune system to target and kill cancer cells.

Dr. Baar has received a prestigious grant from the National Cancer Institute and the Avon Foundation to begin the vaccine trial in January 2009 for women with early stage triple negative breast cancer to see if this vaccine can raise their immune response against MUC-1. If it does, then a later study would be undertaken to determine whether the generation of such an immune response leads to an increase in patients' relapse-free survival rates, thereby preventing recurrence. The vaccine will be administered following standard therapy of surgery, radiation and chemotherapy.

"This vaccine trial has the potential to rev up patients' immune response to the MUC-1 protein and shut down the tumor's ability to grow," says Dr. Baar. "Women with this aggressive triple negative breast cancer have an increased risk of recurrence and we are hoping to provide them with protection against the return of this deadly disease. Our findings that have been presented at the San Antonio Breast Symposium provide us a strong basis for this trial."

Triple negative breast cancer is a highly aggressive form which comprises 10-15 percent of newly diagnosed early stage breast cancer. Most triple negative tumors are high grade and have a high incidence of recurrence and metastases (spreading to other organs). Unlike other types of breast cancer, there is no standard follow-up treatment for triple negative breast cancer to prevent recurrence.

"This is an important study because there has traditionally been nothing to offer women with triple negative breast cancer beyond standard therapy," says Stanton Gerson, MD, Director of the Ireland Cancer Center. "This vaccine trial has the potential to lay the groundwork for a new standard of care for women with this aggressive form of breast cancer."

[Doxiamonev]

Nav, interesting read.
Wow Ruth, glad you have mentioned this as triple negs are appearing more these days-