Metformin suppresses metastasis of triple negative breast ca

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Metformin suppresses metastasis of triple negative breast ca

Postby yowyow » Fri May 06, 2011 6:38 pm

Metformin suppresses metastasis of triple negative breast cancer cells
Last updated: December 5, 2010
News type:Breast cancer study
Publication:Oncology Reports, January 2011
Study name:The anti-diabetic drug metformin suppresses the metastasis-associated protein CD24 in MDA-MB-468 triple-negative breast cancer cells
A new study has reported that metformin reduces the metastatic potential of triple negative breast cancer cells. Metformin is a drug used to treat type 2 diabetes. Diabetic women taking metformin have been shown to have lower risk of breast cancer and better response to chemotherapy than other diabetics. Triple negative disease is a subtype of breast cancer that is estrogen receptor negative (ER-), progesterone receptor negative (PR-), and human epidermal growth factor receptor 2 negative (HER2-). CD24 is a mucin-like adhesion molecule that is involved in cell adhesion and metastatic tumor spread and has been used as a marker of poor prognosis in breast cancer. In fact, distant metastases in breast cancer patients resistant to treatment are thought to be largely composed of CD24-positive cells (CD24 expression rates as high as 85% have been detected). Therefore, new treatments designed to reduce the expression of CD24 could inhibit the spread of breast cancer cells and the formation of metastasis.

In the study, the authors demonstrated that suppression of CD24 expression is an important feature of the mechanism underlying the growth-inhibitory effects of metformin in MDA-MB-468 triple-negative breast cancer cells. The authors first confirmed that triple negative breast cancer cells were significantly more sensitive to the growth-inhibitory effects of metformin than other subtypes of breast cancer. The authors then showed that growth-inhibitory concentrations of metformin greatly reduced CD24 protein levels and that the degree of growth inhibition by metformin was directly related to the proportion of high CD24-expressing cells. Finally, the authors used a breast cancer profiling database to compare distant metastasis-free survival for high-CD24 and low-CD24 breast tumors. The analysis demonstrated that patients with high CD24-expressing tumors tended to have a shorter distant metastasis-free survival. The authors conclude that, taken together, the findings suggest that metformin's ability to suppress CD24 expression may open a new avenue in the treatment of highly-metastatic subgroups of triple-negative breast cancer.

Please see our articles on what triple negative breast cancer patients should eat and the latest research concerning triple negative breast cancer prognosis for more information on triple negative breast cancer.
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