The Met oncogene and basal-like breast cancer:

Technical information including statistics, diagnostic, genetics and research.
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jayem
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Re: The Met oncogene and basal-like breast cancer:

Postby jayem » Fri Sep 17, 2010 6:59 pm

Jan

Dx 20 Sept 2006, 2 cm IDC + DCIS, 1/16+ node, ER+, PR+, HER2-, 4 AC, 4 Taxol, 33 rads
CFEM Trial 5 years Arimidex, 5 year SOLE trial Femara
Dx Aug 2016 neuroendocrine cancer in pancreas, mets to liver, abdominal nodes, hip, skull, scalp and breast.

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Janette
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Re: The Met oncogene and basal-like breast cancer:

Postby Janette » Fri Sep 17, 2010 1:29 pm

It's heavy stuff isn't it? More like a pathology report. :ouch:
Janette


Crystalady
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Re: The Met oncogene and basal-like breast cancer:

Postby Crystalady » Fri Sep 17, 2010 11:19 am

Me too :ouch: :ouch:
First diagnosed in Dec 1998. Thyroid cancer 2006. Thought I was free and clear after 10 years but no, mets in spine in Dec 2008. Femara stopped working October 2010.Was on Aromasin and zometa. Now taking Xeloda and Zometa.Xeloda not working Dec 2011. Tamoxifen started. Feb 2012 Now on Abraxane.

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Gail
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Re: The Met oncogene and basal-like breast cancer:

Postby Gail » Fri Sep 17, 2010 11:18 am

All power to you Janette understanding what that means! My eyes glazed over. lol.
"You Gotta Laugh!"

Gail


Diagnosed April 2006,Lumpectomy,17 of 25 nodes positive, chemo, radiation. Finished treatment March 07
Diagnosed July 2012 cancer of mediastinal(nodes around lungs and heart)pelvis and spine. Up for the fight!

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Janette
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The Met oncogene and basal-like breast cancer:

Postby Janette » Thu Sep 16, 2010 5:45 pm

The Met oncogene and basal-like breast cancer: another culprit to watch out for?
Abstract

Recent findings suggest the involvement of the MET oncogene, encoding the tyrosine kinase receptor for hepatocyte growth factor, in the onset and progression of basal-like breast carcinoma. The expression profiles of basal-like tumors - but not those of other breast cancer subtypes - are enriched for gene sets that are coordinately over-represented in transcriptional signatures regulated by Met. Consistently, tissue microarray analyses have revealed that Met immunoreactivity is much higher in basal-like cases of human breast cancer than in other tumor types. Finally, mouse models expressing mutationally activated forms of Met develop a high incidence of mammary tumors, some of which exhibit basal characteristics. The present review summarizes current knowledge on the role and activity of Met in basal-like breast cancer, with a special emphasis on the correlation between this tumor subtype and the cellular hierarchy of the normal mammary gland.
Janette





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