Long Term Use Oral Bisphosphonates May Double Risk Oesoph CA

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angel33
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Re: Long Term Use Oral Bisphosphonates May Double Risk Oesop

Postby angel33 » Wed Sep 15, 2010 7:50 am

Interesting, I saw that too.
my onc prefferred me having iv biophosphonates....is that the general trend still i wonder?????
cheers
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EBC 1997, bony mets Dec 2000, liver mets april 2007, chemo since

pusathome
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Re: Long Term Use Oral Bisphosphonates May Double Risk Oesop

Postby pusathome » Sun Sep 12, 2010 9:07 pm

Janet thanks for the posted information, very interesting.

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Long Term Use Oral Bisphosphonates May Double Risk Oesoph CA

Postby Janette » Sat Sep 11, 2010 11:24 am

Long Term Use of Oral Bisphosphonates May Double Risk of Oesophageal Cancer

LONDON -- September 6, 2010 -- People who take oral bisphosphonates for bone disease over 5 years may be doubling their risk of developing oesophageal cancer, according to a study published on bmj.com.

Case reports suggest an association between use of oral bisphosphonates for osteoporosis and increased risk of oesophageal cancer, but the evidence is limited, and no adequately large study with information on potential confounding factors and long follow-up has been published.

Therefore, researchers from the University of Oxford's Cancer Epidemiology Unit and the Medicines and Healthcare products Regulatory Agency, Oxford, United Kingdom, carried out a large-scale study to look into the possibility of an association.

They analysed data from the UK General Practice Research Database, which has anonymised patient records for around 6 million people registered with a NHS GP.
They focused on men and women aged over 40 years -- 2,954 with oesophageal cancer, 2,018 with stomach cancer, and 10,641 with colorectal cancer diagnosed between 1995 and 2005. Each case was compared with 5 controls matched for age, sex, general practice, and observation period.

They found that people with 10 or more prescriptions, or with prescriptions over about 5 years, had nearly double the risk of oesophageal cancer compared with people with no bisphosphonate prescriptions.

There was no such increased risk for stomach or colorectal cancer.

Typically, oesophageal cancer develops in 1 per 1000 people aged 60 to 79 over 5 years. Based on the findings, the authors estimated that with 5 years' use of oral bisphosphonates, this would increase to 2 cases per 1000 people taking bisphosphonates over 5years.

Although these results appear to contradict another recently published study using the same database, which reported no increased risk of oesophageal cancer with oral bisphosphonate use, this study tracked patients for nearly twice as long, and also had greater statistical power.

In an accompanying editorial, Diane Wysowski, MD, from the US Food and Drug Administration (FDA), Rockville, Maryland, discusses the differences between the 2 studies. She said that "the possibility of adverse effects on the oesophagus should prompt doctors who prescribe these drugs to consider risks versus benefits." She also suggests doctors "tell patients to report difficulty in swallowing and throat, chest, or digestive discomfort so that they can be promptly evaluated and possibly advised to discontinue the drug."

SOURCE: British Medical Journal
Janette



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