"Smart Bomb" Drug Attacks Breast Cancer

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KakaCathFreeSpirit
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Re: "Smart Bomb" Drug Attacks Breast Cancer

Postby KakaCathFreeSpirit » Fri Jun 08, 2012 6:43 pm

T-DM1 is a smart-drug indeed, though not smart enough ! but wait, Im sure there's more on the way now its know that Trastuzumab ( Herceptin ) can deliver its cargo while packing a punch, thats for sure. The Chemo side of the drug is way too toxic to administer intravenously into the blood-stream, the Chemotherapy ( cytotoxic ) part of the combo-drug is call " Emtansine"....Together it makes T-DM1, the "T'' stands for Trastuzumab ( Herceptin ) the ''DM1'' is the ''Emtansine'' part.

Lets hope that long runs of T-DM1 has much better outcomes, rather than only the 6 to 12 months PFS ( progression free survival ) as listed at the ASCO ( American Society of Clinical Oncology ) has predicted, after all that is a similar time expectancy they said when Herceptin was approved by the FDA in 1998.

Our good friend Herceptin may deliver many goodies for the bad-guys to suck-up, yum-yum one for you, and one for you, and one for youuuu.....
Life in progress age 44 misdiagnosed to diagnosed 2010, IDC 2cm x1 IDC 1cm x1 DCIS x lots !
ER-PR-HER2++ 5/24 node positive, stage 2/3, grade 2, mastectomy x2, right-prophylactic, chemo, rads, Herceptin, Neratinib clinical drug trial x1yr, Denosumab 4 osteoporosis

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Re: "Smart Bomb" Drug Attacks Breast Cancer

Postby dawny » Thu Jun 07, 2012 11:12 am

Yes, it is on trial in Geelong, but only for early stagers, I heard it will be available for all late 2013. I wish they would just hurry up!
Dawn
Dx May 2011 Stage 1V mets to lung, chest and neck Abraxane 3 weeks on 1 week off for 16 weeks, Herceptin every 3 weeks, Scans Sept 2011 show NED! Brain MRI Dec 2011 - clear, CT/bone scans Dec 2011 show NED!
March 2012 axillary node, watching and waiting. May 2012, plus chest node, need a new plan!

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chrismelb
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Re: "Smart Bomb" Drug Attacks Breast Cancer

Postby chrismelb » Tue Jun 05, 2012 7:48 pm

I think the chemo is attached to the anti her-2 agent so it gets directly into cell. Called TDM 1. I want it!
Dx 9/03 EBC
5/12 ABC bones-Herceptin,Tamox&Zometa
8/12 Liver mets-Abraxane,Herceptin&Zometa
6/13 Xeloda/Tykerb Xgeva
11/14 TDM1 Xgeva
1/15 Rads to tumour in head
2/16 Whole brain rads lepto. mets, continue TDM1
8/16. Navelbine, Herceptin
1/17 Neratanib Xeloda & Herceptin.

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Janette
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Re: "Smart Bomb" Drug Attacks Breast Cancer

Postby Janette » Tue Jun 05, 2012 4:08 pm

I'm sorry to hear about your friend's hip replacement, I hope it greatly improves her situation.

Good that you posted even if in the future. Probably not long ago that Herceptin and Tykerb, were future treatments and look how widely used they are. :hugs:
Janette


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Re: "Smart Bomb" Drug Attacks Breast Cancer

Postby RedHen » Tue Jun 05, 2012 1:51 pm

I don't know much about it at all but thought it was worth posting. I guess you would all get a bit sick of hearing about these things and then finding out they're years away. Good news for future generations though, I guess that's something. All the best to you.

My friend has just had a hip replacement due to a cancer fracture in her pelvis - she's 49. Oh my god it's a dreadful disease, not that any of you need me to tell you that.
A close friend was diagnosed with primary and advanced breast cancer (bone mets) early 2010.

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Re: "Smart Bomb" Drug Attacks Breast Cancer

Postby jezza » Tue Jun 05, 2012 1:14 pm

yes thanks Redhen. I caught the end of a bulletin on the news about it and couldn't really understand. It does sound exciting, They always seem to announce these things and then say they won't be available for xx amount of time.

Very frustrating if you're one of the ones who may benefit from it.

The lower instances of SEs sounds especially promising.

jezza
Dx Jan. 1992 9mm Grade 3 IDC node neg. LB mast. Prophylactic RB mast. 6 months later. No chemo. No rads. Saline implants. 22 years NED. (No Evidence of Disease)

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Re: "Smart Bomb" Drug Attacks Breast Cancer

Postby chrismelb » Sun Jun 03, 2012 11:21 pm

I have seen it mentioned a lot on HER-2 support forum but never been sure what it was. I think it is a more sophisticated form of Herceptin.
Dx 9/03 EBC
5/12 ABC bones-Herceptin,Tamox&Zometa
8/12 Liver mets-Abraxane,Herceptin&Zometa
6/13 Xeloda/Tykerb Xgeva
11/14 TDM1 Xgeva
1/15 Rads to tumour in head
2/16 Whole brain rads lepto. mets, continue TDM1
8/16. Navelbine, Herceptin
1/17 Neratanib Xeloda & Herceptin.

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Re: "Smart Bomb" Drug Attacks Breast Cancer

Postby schoolteacher » Sun Jun 03, 2012 10:00 pm

My oncologist mentioned this week that there were many new targeted therapies for Her2+. she was reassuring me that if Her2 is going to return it is usually in 2 years and I am past that date. I mentioned our recently diagnosed members :(

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Janette
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Re: "Smart Bomb" Drug Attacks Breast Cancer

Postby Janette » Sun Jun 03, 2012 7:39 pm

Thanks Red Hen, having some members with Her2+ newly diagnosed secondaries, as well all our members with Her2+, this treatment cannot come soon enough. Let's hope it continues to prove successful.
Janette




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"Smart Bomb" Drug Attacks Breast Cancer

Postby RedHen » Sun Jun 03, 2012 5:35 pm

From http://www.news.com.au/breaking-news/wo ... 6381838552

DOCTORS have successfully dropped the first "smart bomb" on breast cancer, using a drug to deliver a toxic payload to tumor cells while leaving healthy ones alone.

In a key test involving nearly 1000 women with very advanced disease, the experimental treatment extended by several months the time women lived without their cancer getting worse, doctors planned to report tonight at a cancer conference in Chicago.

More importantly, the treatment seems likely to improve survival; it will take more time to know for sure.

After two years, 65 per cent of women who received it were still alive versus 47 per cent of those in a comparison group given two standard cancer drugs.

That margin fell just short of the very strict criteria researchers set for stopping the study and declaring the new treatment a winner, and they hope the benefit becomes more clear with time.

In fact, so many women on the new treatment are still alive that researchers cannot yet determine average survival for the group.

"The absolute difference is greater than one year in how long these people live," said the study's leader, Dr Kimberly Blackwell of Duke University. "This is a major step forward."

A warning to hopeful patients: the drug is still experimental, so not available yet. Its backers hope it can reach the market within a year.

The treatment builds on Herceptin, the first gene-targeted therapy for breast cancer. It is used for about 20 per cent of patients whose tumors overproduce a certain protein.

Researchers combined Herceptin with a chemotherapy so toxic that it can't be given by itself, plus a chemical to keep the two linked until they reach a cancer cell where the poison can be released to kill it.

This double weapon, called T-DM1, is the "smart bomb," although it's actually not all that smart - Herceptin isn't a homing device, just a substance that binds to breast cancer cells once it encounters them.

Doctors tested T-DM1 in 991 women with widely spread breast cancer that was getting worse despite treatment with chemotherapy and ordinary Herceptin. They were given either T-DM1 infusions every three weeks or infusions of Xeloda plus daily Tykerb pills - the only other treatments approved for such cases.

The median time until cancer got worse was nearly 10 months in the women given T-DM1 versus just over 6 months for the others. That is about the same magnitude of benefit initially seen with Herceptin, which later proved to improve overall survival, too, Blackwell said.

T-DM1 caused fewer side effects than the other drugs did. Some women on T-DM1 had signs of liver damage and low levels of factors that help blood clot, but most did not have the usual problems of chemotherapy.

"People don't lose their hair, they don't throw up. They don't need nausea medicines, they don't need transfusions," said Dr Blackwell, who has consulted in the past for Genentech, the study's sponsor.

"The data are pretty compelling," said Dr Michael Link, a pediatric cancer specialist at Stanford University who is president of the American Society of Clinical Oncology, the group hosting the Chicago conference where the results were being presented.

"It's sort of a smart bomb kind of therapy, a poison delivered to the tumor ... and not a lot of other collateral damage to other organs," he said.
A close friend was diagnosed with primary and advanced breast cancer (bone mets) early 2010.


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