bisphonates & HR negative bccr & bone metastases

Information about conventional breast cancer treatments - inc surgery, chemo, rads, hormonal, reconstruction, lymphedema, side effects
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cheryl
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bisphonates & HR negative bccr & bone metastases

Postby cheryl » Fri May 22, 2009 1:57 pm

this is from BCMets today.

Research article
Potential antitumor effects of nitrogen-containing bisphosphonate in hormone
receptor negative breast cancer patients with bone metastases
In Hae Park , Jungsil Ro , Byung Ho Nam , Youngmi Kwon and Keun Seok Lee
BMC Cancer 2009, 9:154doi:10.1186/1471-2407-9-154

Published:20 May 2009

Abstract (provisional)

Background
This retrospective study evaluated, according to hormone receptor status,
the antitumor effects of bisphosphonate in breast cancer patients with
metastatic bone disease.

Methods
Of 317 patients with initial bone metastasis and known breast cancer
subtypes, 230 patients (72.6%) had hormone receptor (HR) positive tumors,
and 87 patients (27.4%) had HR negative tumors. We assessed the primary
outcome of overall survival (OS), after adjusting for other factors,
comparing a group that received bisphosphonates (BPs) with a group that did
not receive it.

Results
87.8% of HR positive and 69.0% of HR negative patients received BPs with a
median number of 17.7 cycles. Although BPs treatment made no survival
benefit in HR positive group, HR negative patients showed a significant
prolonged survival when they received BPs treatment (hazard ratio=0.56 [95%
CI 0.34 to 0.91], P = 0.019). In multivariate analysis, disease free
interval > 2 years (P = 0.036), a sum of metastatic sites < 3 (P = 0.034),
and BP treatments (P = 0.007) were significant factors for survival in HR
negative patients. Conclusions: Bisphosphonate treatment can result in a
survival benefit in metastatic breast cancer patients with HR negative
tumors.
Cheryl

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