PATINA clinical trial

For those wanting to share with others living with secondary or metastatic breast cancer.
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Pamelamary
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Re: PATINA clinical trial

Postby Pamelamary » Sun Oct 15, 2017 6:10 pm

Interesting for those of us who are Her2+ and Er+..... Pam

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Breast Cancer Trials
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PATINA clinical trial

Postby Breast Cancer Trials » Mon Oct 09, 2017 12:49 pm

This study is open to people diagnosed with hormone receptor (HR) positive, Human Epidermal Growth Factor Receptor 2 (HER-2) positive metastatic breast cancer. Metastatic breast cancer is cancer that has spread from the primary site (breast) to other parts of the body (distant sites). HER2 is a receptor which is known to promote cancer growth when present in levels above normal. Despite significant improvements in the treatment of early-stage breast cancer, approximately 30% of women experience metastatic disease relapse. Development of therapies targeting the HER2 receptor has dramatically improved patient outcomes.

The PATINA study aims to find out if people with metastatic breast cancer could benefit from the addition of a new drug, Palbociclib, when given in combination with anti-HER2 therapy (trastuzumab and pertuzumab) and endocrine therapy. Trastuzumab and pertuzumab are designed to target HER-2 and block its role in tumour cell growth and survival. They are currently used in Australia for the first line treatment of metastatic HER-2 positive breast cancer together with a class of chemotherapy called taxanes. Endocrine treatment is standard of care for the treatment of HR positive breast cancer. Endocrine treatment prevents breast cancer cell growth by blocking the action of hormone receptors. After a period of treatment with all three drugs at the same time (also called “induction therapy”), the pertuzumab and trastuzumab therapy may be continued without chemotherapy.

More information is available on our website. If interested, speak with your doctor to see if this trial may be suitable for you.



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